diff --git a/tsc/internal/checker/relater.go b/tsc/internal/checker/relater.go
index d3b6c86014498..7f92837be4a83 100644
--- a/tsc/internal/checker/relater.go
+++ b/tsc/internal/checker/relater.go
@@ -3473,6 +3473,20 @@ func (r *Relater) structuredTypeRelatedToWorker(source *Type, target *Type, repo
 			}
 			return TernaryFalse
 		}
+		if r.relation == r.c.comparableRelation && source.flags&TypeFlagsTypeParameter == 0 {
+			// An unconstrained type parameter target could be instantiated with anything, so any
+			// source could overlap with it. This mirrors the source-side constraint check below;
+			// without it, types nested inside properties or construct signature return types (see
+			// issue #27910) are treated as non-overlapping on this side alone. Type parameters
+			// with an object constraint stay strict to preserve TS2352/TS2367 checks against
+			// instantiations with a different subtype of the constraint.
+			constraint := r.c.getConstraintOfType(target)
+			if constraint == nil || constraint.flags&TypeFlagsAnyOrUnknown != 0 {
+				if result := r.isRelatedToEx(source, r.c.unknownType, RecursionFlagsTarget, false /*reportErrors*/, nil /*headMessage*/, intersectionState); result != TernaryFalse {
+					return result
+				}
+			}
+		}
 	case target.flags&TypeFlagsIndexedAccess != 0:
 		if source.flags&TypeFlagsIndexedAccess != 0 {
 			// Relate components directly before falling back to constraint relationships
diff --git a/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.errors.txt b/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.errors.txt
new file mode 100644
index 0000000000000..d969dbb8af495
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.errors.txt
@@ -0,0 +1,38 @@
+comparableRelationTypeParameterTarget.ts(29,9): error TS2367: This comparison appears to be unintentional because the types 'T' and 'U' have no overlap.
+
+
+==== comparableRelationTypeParameterTarget.ts (1 errors) ====
+    // Reproduces #27910: a generic constructor type must be comparable with a concrete
+    // constructor it could overlap with. Previously, `Constructor<T> === typeof Child`
+    // reported TS2367 ("no overlap") even though `func(Child)` accepted `Child` as
+    // `Constructor<T>`.
+    
+    interface Item { }
+    
+    abstract class Base<T> {
+        get Item(): T { throw 0 }
+    }
+    
+    class Child extends Base<Item> {
+        constructor(public data: any) { super() }
+    }
+    
+    type Constructor<T> = new (data: any) => Base<T>
+    
+    function func<T>(constructor: Constructor<T>): void {
+        if (constructor === Child) {
+            // do something
+        }
+        new constructor(null)
+    }
+    
+    func(Child);
+    
+    // Two unrelated type parameters still have no overlap.
+    function unrelated<T, U>(x: T, y: U): void {
+        if (x === y) {
+            ~~~~~~~
+!!! error TS2367: This comparison appears to be unintentional because the types 'T' and 'U' have no overlap.
+        }
+    }
+    
\ No newline at end of file
diff --git a/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.symbols b/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.symbols
new file mode 100644
index 0000000000000..b5a69f1c92fa7
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.symbols
@@ -0,0 +1,74 @@
+//// [tests/cases/compiler/comparableRelationTypeParameterTarget.ts] ////
+
+=== comparableRelationTypeParameterTarget.ts ===
+// Reproduces #27910: a generic constructor type must be comparable with a concrete
+// constructor it could overlap with. Previously, `Constructor<T> === typeof Child`
+// reported TS2367 ("no overlap") even though `func(Child)` accepted `Child` as
+// `Constructor<T>`.
+
+interface Item { }
+>Item : Symbol(Item, Decl(comparableRelationTypeParameterTarget.ts, 0, 0))
+
+abstract class Base<T> {
+>Base : Symbol(Base, Decl(comparableRelationTypeParameterTarget.ts, 5, 18))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 7, 20))
+
+    get Item(): T { throw 0 }
+>Item : Symbol(Base.Item, Decl(comparableRelationTypeParameterTarget.ts, 7, 24))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 7, 20))
+}
+
+class Child extends Base<Item> {
+>Child : Symbol(Child, Decl(comparableRelationTypeParameterTarget.ts, 9, 1))
+>Base : Symbol(Base, Decl(comparableRelationTypeParameterTarget.ts, 5, 18))
+>Item : Symbol(Item, Decl(comparableRelationTypeParameterTarget.ts, 0, 0))
+
+    constructor(public data: any) { super() }
+>data : Symbol(Child.data, Decl(comparableRelationTypeParameterTarget.ts, 12, 16))
+>super : Symbol(Base, Decl(comparableRelationTypeParameterTarget.ts, 5, 18))
+}
+
+type Constructor<T> = new (data: any) => Base<T>
+>Constructor : Symbol(Constructor, Decl(comparableRelationTypeParameterTarget.ts, 13, 1))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 15, 17))
+>data : Symbol(data, Decl(comparableRelationTypeParameterTarget.ts, 15, 27))
+>Base : Symbol(Base, Decl(comparableRelationTypeParameterTarget.ts, 5, 18))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 15, 17))
+
+function func<T>(constructor: Constructor<T>): void {
+>func : Symbol(func, Decl(comparableRelationTypeParameterTarget.ts, 15, 48))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 17, 14))
+>constructor : Symbol(constructor, Decl(comparableRelationTypeParameterTarget.ts, 17, 17))
+>Constructor : Symbol(Constructor, Decl(comparableRelationTypeParameterTarget.ts, 13, 1))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 17, 14))
+
+    if (constructor === Child) {
+>constructor : Symbol(constructor, Decl(comparableRelationTypeParameterTarget.ts, 17, 17))
+>Child : Symbol(Child, Decl(comparableRelationTypeParameterTarget.ts, 9, 1))
+
+        // do something
+    }
+    new constructor(null)
+>constructor : Symbol(constructor, Decl(comparableRelationTypeParameterTarget.ts, 17, 17))
+}
+
+func(Child);
+>func : Symbol(func, Decl(comparableRelationTypeParameterTarget.ts, 15, 48))
+>Child : Symbol(Child, Decl(comparableRelationTypeParameterTarget.ts, 9, 1))
+
+// Two unrelated type parameters still have no overlap.
+function unrelated<T, U>(x: T, y: U): void {
+>unrelated : Symbol(unrelated, Decl(comparableRelationTypeParameterTarget.ts, 24, 12))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 27, 19))
+>U : Symbol(U, Decl(comparableRelationTypeParameterTarget.ts, 27, 21))
+>x : Symbol(x, Decl(comparableRelationTypeParameterTarget.ts, 27, 25))
+>T : Symbol(T, Decl(comparableRelationTypeParameterTarget.ts, 27, 19))
+>y : Symbol(y, Decl(comparableRelationTypeParameterTarget.ts, 27, 30))
+>U : Symbol(U, Decl(comparableRelationTypeParameterTarget.ts, 27, 21))
+
+    if (x === y) {
+>x : Symbol(x, Decl(comparableRelationTypeParameterTarget.ts, 27, 25))
+>y : Symbol(y, Decl(comparableRelationTypeParameterTarget.ts, 27, 30))
+    }
+}
+
diff --git a/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.types b/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.types
new file mode 100644
index 0000000000000..8fe1f03ed09d4
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/comparableRelationTypeParameterTarget.types
@@ -0,0 +1,66 @@
+//// [tests/cases/compiler/comparableRelationTypeParameterTarget.ts] ////
+
+=== comparableRelationTypeParameterTarget.ts ===
+// Reproduces #27910: a generic constructor type must be comparable with a concrete
+// constructor it could overlap with. Previously, `Constructor<T> === typeof Child`
+// reported TS2367 ("no overlap") even though `func(Child)` accepted `Child` as
+// `Constructor<T>`.
+
+interface Item { }
+
+abstract class Base<T> {
+>Base : Base<T>
+
+    get Item(): T { throw 0 }
+>Item : T
+>0 : 0
+}
+
+class Child extends Base<Item> {
+>Child : Child
+>Base : Base<Item>
+
+    constructor(public data: any) { super() }
+>data : any
+>super() : void
+>super : typeof Base
+}
+
+type Constructor<T> = new (data: any) => Base<T>
+>Constructor : Constructor<T>
+>data : any
+
+function func<T>(constructor: Constructor<T>): void {
+>func : <T>(constructor: Constructor<T>) => void
+>constructor : Constructor<T>
+
+    if (constructor === Child) {
+>constructor === Child : boolean
+>constructor : Constructor<T>
+>Child : typeof Child
+
+        // do something
+    }
+    new constructor(null)
+>new constructor(null) : Base<T>
+>constructor : Constructor<T>
+}
+
+func(Child);
+>func(Child) : void
+>func : <T>(constructor: Constructor<T>) => void
+>Child : typeof Child
+
+// Two unrelated type parameters still have no overlap.
+function unrelated<T, U>(x: T, y: U): void {
+>unrelated : <T, U>(x: T, y: U) => void
+>x : T
+>y : U
+
+    if (x === y) {
+>x === y : boolean
+>x : T
+>y : U
+    }
+}
+
diff --git a/tsc/testdata/tests/cases/compiler/comparableRelationTypeParameterTarget.ts b/tsc/testdata/tests/cases/compiler/comparableRelationTypeParameterTarget.ts
new file mode 100644
index 0000000000000..276c5443e6b4b
--- /dev/null
+++ b/tsc/testdata/tests/cases/compiler/comparableRelationTypeParameterTarget.ts
@@ -0,0 +1,34 @@
+// @noEmit: true
+// @strict: true
+
+// Reproduces #27910: a generic constructor type must be comparable with a concrete
+// constructor it could overlap with. Previously, `Constructor<T> === typeof Child`
+// reported TS2367 ("no overlap") even though `func(Child)` accepted `Child` as
+// `Constructor<T>`.
+
+interface Item { }
+
+abstract class Base<T> {
+    get Item(): T { throw 0 }
+}
+
+class Child extends Base<Item> {
+    constructor(public data: any) { super() }
+}
+
+type Constructor<T> = new (data: any) => Base<T>
+
+function func<T>(constructor: Constructor<T>): void {
+    if (constructor === Child) {
+        // do something
+    }
+    new constructor(null)
+}
+
+func(Child);
+
+// Two unrelated type parameters still have no overlap.
+function unrelated<T, U>(x: T, y: U): void {
+    if (x === y) {
+    }
+}